2026
Locations of consecutive G・C base pairs direct genomic nucleosome positioning.
Kato H, Fuse T, Sato S, Kurihara Y, Kagawa W, Urano T, Ohkawa Y, Kurumizaka H, Shimizu M.
Genome Research (in press) DOI: 10.1101/gr.281372.125
Structural basis of nucleosome remodeling by Cockayne syndrome B homologue Komagataella phaffii Rad26.
Fukushima Y, Kinoshita C, Negishi L, Kujirai T, Kobayashi Y, Ogasawara M, Ehara H, Sekine SI, Kagawa W, Kurumizaka H, Takizawa Y.
Nature Communications 17, 4881. DOI: 10.1038/s41467-026-73500-7
2024
Heavy water inhibits DNA double-strand break repairs and disturbs cellular transcription, presumably via quantum-level mechanisms of kinetic isotope effects on hydrolytic enzyme reactions.
Yasuda T, Nakajima N, Ogi T, Yanaka T, Tanaka I, Gotoh T, Kagawa W, Sugasawa K, Tajima K.
PLoS One 19, e0309689. DOI: 10.1371/journal.pone.0309689
2023
Structural Basis of Damaged Nucleotide Recognition by Transcribing RNA Polymerase II in the Nucleosome.
Osumi K, Kujirai T, Ehara H, Ogasawara M, Kinoshita C, Saotome M, Kagawa W, Sekine SI, Takizawa Y, Kurumizaka H.
Journal of Molecular Biology 435, 168130. DOI: 10.1016/j.jmb.2023.168130
Biochemical characterization of the RNA-binding and RNA-DNA strand exchange activities of the human RAD52 protein.
Tsuchiya R, Saotome M, Kinoshita C, Kamoi K, Kagawa W.
Journal of Biochemistry 174, 59-69. DOI: 10.1093/jb/mvad019
The cryo-EM structure of full-length RAD52 protein contains an undecameric ring.
Kinoshita C, Takizawa Y, Saotome M, Ogino S, Kurumizaka H, Kagawa W.
FEBS Open Bio 13, 408-418. DOI: 10.1002/2211-5463.13565
2021
Structural basis for DNA sequence recognition by pioneer factors in nucleosomes.
Kagawa W, Kurumizaka H.
Currrent Opinion in Structural Biology 71, 59-64. DOI: 10.1016/j.sbi.2021.05.011
Human SIRT2 and SIRT3 deacetylases function in DNA homologous recombinational repair.
Yasuda T, Takizawa K, Ui A, Hama M, Kagawa W, Sugasawa K, Tajima K.
Genes to Cells 26, 328-335. DOI: 10.1111/gtc.12842